Associate Professor Che-Chien Chang

Phone

Phone:

(office) +886-2-2905-3564

(lab) +886-2-2905-3562

(fax) +886-2-2902-3209

E-mail

080686@mail.fju.edu.tw

Link

 

Experiences and

honors:

B.S. 1997, National Chung-Hsing University (Prof. T.-J. Lu)

M.S. 1999, National Taiwan University (Prof. J.-M. Fang)

Ph.D. 2007, National Taiwan University (Prof. Y.-M. Tsai)

 

Teaching assistant, 2000, National Taiwan University

Research assistant, 2002, Academia Sinica (Dr. C.-H. Lin)

Visiting Ph.D. student, 2006, University of Münster, Germany (Prof. A. Studer)

Postdoctoral Fellow, 2008, University of Alberta, Canada (Prof. D. L. J. Clive)

Postdoctoral Fellow, 2009, Northwestern University, USA (Prof. R. B. Silverman)

Postdoctoral Fellow, 2010, School of Pharmacy, NTU (Prof. S.-S. Lee)

Assistant Professor, 2010, Fu Jen University

Associate Professor, 2015, Fu Jen University

Professor, 2021.02~ , Fu Jen University

 

Awards:

DAAD-Sandwich scholarship(2005-2006), sponsored by DAAD-Germany and NSC-Taiwan

Field

Organic synthesis, Bioorganic chemistry, Radical polymerization

Research Interests

My lab is focusing on some research topics, related to organic synthesis. Through total synthesis of natural products and development of synthetic methodologies, we hope to find more potent organic molecules, which could be drug-like molecules, enzyme inhibitors, agonists, and antagonists…etc. Meanwhile, we have combined polymer science with carbohydrate chemistry to prepare interesting biomedical glycopolymers. 

Recent Publications

代表著作：

Independent research (獨立研究工作，唯一通訊作者)

19.   Cascade Vinyl Radical Ipso-Cyclization Reactions and the Formation of a,b-Unsaturated-b-aryl-g-lactams from N-Propargyl Benzamides

        Chih-Hao Luo, Pei-Ling Wang, Che-Chien Chang*

     J. Org. Chem. 2021, 86, 15033-15044.

18.   Conversion of a Readily Available Carbohydrate Raw Material into a Rare L-Deoxyhexose

        Ya-Han Hsu, Che-Chien Chang*

        Tetrahedron Lett. 2021, 63, 152718.

17. Design and Synthesis of Trivalent Tn Glycoconjugate Polymers by Nitroxide-Mediated Polymerization

Si-Xian Liu, Yun-Tzu Tsai, Yu-Tung Lin, Jia-Yue Li, and Che-Chien Chang*

Tetrahedron 2019, 75, 130776.

16.   Synthesis of L-Deoxyribonucleosides from D-Ribose.

Wei-Syun Song, Si-Xian Liu, and Che-Chien Chang*

J. Org. Chem. 2018, 83, 14923-14932. 

15.  Chemical Synthesis of Ketopentose-5-phosphates.

Wei-Chih Wei and Che-Chien Chang*

Eur. J. Org. Chem. 2017, 3033-3040. 

獲選為當期的期刊封面故事: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201700685/full

14.  Synthesis of 3-Deoxy-L-ketohexoses Through Group Transfer.

Tai-Ni Lu and Che-Chien Chang*

J. Org. Chem. 2016, 81, 469-475. 

13.  Radical Cyclization Followed by the Fragmentation of Carbonyl Compounds: Effect of an alpha-Benzoyl Group.

Li-An Chien and Che-Chien Chang*

J. Org. Chem. 2015, 80, 11294-11301. 

12.  Chemical synthesis of 1-deoxy-L-fructose and L-sorbose through carbonyl translocation.

Hsin-Pei Wu, Nai-Yun Hsu, Tai-Ni Lu, and Che-Chien Chang*

Eur. J. Org. Chem. 2015, 378-382.

11.  Synthetic mimics of carbohydrate-based anticancer vaccines: preparation of carbohydrate polymers bearing unimolecular trivalent carbohydrate ligands by controlled living radical polymerization.

Teng-Yuan Kuo, Li-An Chien, Ya-Chi Chang, Shuang-Yu Liou, and Che-Chien Chang*

RSC Adv., 2014, 4, 47066-47075.

10.    The absolute stereochemical assignment of SCH 71450, a selective dopamine D4 receptor antagonist, through the enantioselective epimer synthesis.

Hsin-Pei Wu, Tai-Ni Lu, Nai-Yun Hsu, and Che-Chien Chang*

Eur. J. Org. Chem. 2013, 2898-2905.

9.     A unique synthetic method to convert a D-sugar into 2-deoxy-L-ribitol through carbonyl translocation.

Nai-Yun Hsu and Che-Chien Chang*

Eur. J. Org. Chem. 2013, 658-661.

 

 

Selected Invited Lectures (重要會議邀請演講)

 

Dec 12, 2019, Session 78-3, The 18th Asian Chemical Congress (18ACC), Taipei, Taiwan

“Formal Total Synthesis of Telbivudine (L-dT)”

Nov 22, 2018, SIL-12A, The 13th International Symposium on Organic Reactions (ISOR-13), Hsinchu, Taiwan.

“Synthesis of L-Deoxyribonucleosides from D-Ribose”

Apr 22, 2016, SIL-2B, The 12th International Symposium on Organic Reactions (ISOR-12), Kyoto, Japan.

“Carbonyl Translocation in the Synthesis of Deoxysugars”

May 01, 2015, 科技部有機合成小組研討會, 中興大學惠蓀林場

“Radicals in the Synthesis of Deoxysugars and Glycopolymers”

Dec 04, 2010, 中國化學會年會, 台灣大學浦大邦講堂

“Antagonism of Dihydropyridines Toward Voltage Dependent Ca2+ Channels, Cav1.3 and Cav1.2”

 

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Before FJCU

 

Postdoc work (Canada and United States)

8.     Farzad Malihi, Derrick. L. J. Clive,* Che-Chien Chang and Minaruzzaman, Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-Wittig rearrangement, J. Org. Chem. 2013, 78, 996-1013.     (with Clive)

7.     Che-Chien Chang, Song Cao, Soosung Kang, Li Kai, Xinyong Tian, Prativa Pandey, Sara Fernandez Dunne, Chi-Hao Luan, D. James Surmeier*, Richard B. Silverman*, Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Cav1.3 and Cav1.2, Bioorg. Med. Chem. 2010, 18, 3147-3158.     (with Silverman)

 

PhD work (Taiwan and Germany)

6.   Che-Chien Chang, Yu-Hsien Kuo and Yeun-Min Tsai*, The synthesis of carbohydrate-derived acylsilanes and their intramolecular free radical cyclization with the formation of polyoxygenated cyclopentanes, Tetrahedron Lett. 2009, 50, 3805-3808.       (with Tsai)

5.   Che-Chien Chang, Kai O. Siegenthaler and Armido Studer*, A new sterically highly hindered 7-membered cyclic nitroxide for the controlled living radical polymerization, Helv. Chim. Acta, 2006, 89, 2200-2210. (with Studer)

4.     Che-Chien Chang and Armido Studer*, Acceleration of the styryl-TEMPO mediated controlled radical styrene-polymerization by addition of an efficient alkoxyamine, Macromolecules, 2006, 39, 4062-4068.               (with Studer)

 

Before PhD

3.     Wen-Bin Yang, Yu-ing Yang, Yu-Feng Gu, Shwu-Huey Wang, Che-Chien Chang, and Chun-Hung Lin*, Stereochemistry in the synthesis and reaction of exo-glycals, J. Org. Chem. 2002, 67, 3773-3782.

2.     Chuan-Fa Chang, Wen-Bin Yang, Che-Chien Chang and Chun-Hung Lin*, Inter- and intramolecular alcohol additions to exo-glycals, Tetrahedron Lett. 2002, 43, 6515-6519.

1.     Wen-Bin Yang, Chung-Yi Wu, Che-Chien Chang, Shwu-Huey Wang, Chin-Fen Teo and Chun-Hung Lin*, Facile synthesis of conjugated exo-glycals, Tetrahedron lett. 2001, 42, 6907-6910.

 

 

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