Assistant Professor   Wei-Min Liu

https://scontent.xx.fbcdn.net/hphotos-ash2/v/t1.0-9/561930_3564308502113_938061353_n.jpg?oh=495012ecb3051120292c6ea309e05919&oe=57284A8C

Phone

(O) 02-2905-2474  

(LAB) 02-2905-3584

E-mail

133797@mail.fju.edu.tw

Education

2005 B.A. National Taiwan Normal University.

2007 M.A. National Taiwan University.

2013 Ph.D. Leiden University, The Netherlands.

Career

2007 - 2008    Chemistry Teacher     New Taipei Municipal Zhonghe Senior High School, Taiwan

2008- 2009    Teaching assistant        National Taiwan University, Taiwan

2014 - 2015    postdoctoral researcher, Oxford University, U.K.

2015 - 2016    Researcher, Sunny Pharmatech., Taiwan

2016 - present   Assistant Professor, Fu Jen Catholic university, Taiwan

Honor

l   2008 48th National and Private High School Science Fair Excellent Work from Ministry of Education R. O. C.

l   2007 Outstanding Graduate Research Poster Award from Department of Chemistry, NTU (awarded to top 20% research excellence)

l   2007 Excellent Oral Presentation Award from Department of Chemistry, NTU (awarded for clarity of oral presentation)

l   2006 Excellent Organic Graduate Research Poster Award from Chinese Chemical Society (awarded to top 15% research posters nationwide)

Field

有機化學合成、生物有機

Research Interests

1.     利用有機催化劑(organocatalyst)進行不對稱催化反應

2.     設計及合成分子探針，運用在重要生物問題上的探討

受邀演講

l   2014.11 Oral presentation at National Cheng Kung University

l   2013.09 Oral presentation at Opening of the Paramagnetic NMR Facility Leiden

l   2012.10 Oral presentation at 2012 Annual Meeting of NWO-Chemical Sciences study group meeting for Organic Chemistry & Synthesis

l   2011.04 Oral presentation at National Wageningen symposium

Recent Publications

1.        Shih-Ting Ma, Chia-Wei Lee and Wei-Min Liu* “Synthesis of 4-thiol-furanosidic uronate via hydrothiolation reaction” RSC Adv. 2021, 11, 18409.

2.        Kuan-Hsuan Su, Chin-Teng Wu, Shang-Wei Lin, Seiji Mori, Wei-Min Liu*, and Hsiao-Ching Yang* “Calculation of CYP450 protein–ligand binding and dissociation free energy paths” J. Chem. Phys. 2021, 155, 025101.

3.        W.-L. Chen; S.-T. Ma; Y.-W. Chen; Y.-C. Chao; A.-C. Chan; L.-H. Tu* and W.-M. Liu* “A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design” Biochemistry 2020, 59, 1482-1492.

4.        詹璦綺, 林品菡, 劉維民*, 杜玲嫻* “螢光小分子用於偵測類澱粉蛋白聚集” 化學 2020年，第七十八卷，35-47 頁

5.        Miao, Q.; Liu, W.-M.; Kock, T.; Blok, A.J.; Timmer, M.; Overhand, M. & Ubbink, M＊ “A double-armed, hydrophilic, transition metal complex as paramagnetic NMR probe” Angew. Chem. Int. Ed. 2019, 131, 13227-13234. 

6.        Y.Y. Dong; H. Wang; A.C.W. Pike; S.A. Cochrane; S. Hamedzadeh; F.J. Wyszyński; S.R. Bushell; S.F. Royer; D.A. Widdick; A. Sajid; H.I. Boshoff; Y. Park; R. Lucas; W-M. Liu; S.S. Lee; T. Machida; S. Mehmood; K. Belaya; W. Liu; A. Chu; L. Shrestha; S.M. Mukhopadhyay; N. Burgess-Brown; M.J. Bibb; C.E. Barry; C.V. Robinson; D. Beeson; B.G. Davis＊ and E.P. Carpenter＊ “Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design” Cell 2018, 175, 1045-1058.

7.        Andralojc, W.; Hiruma, Y.; Liu, W. –M,; Ravera E.; Nojiri M.; Parigi G.; Luchinat C. and Ubbink M＊ “Identification of productive and futile encounters in an electron transfer protein complex“ Proc. Natl. Acad. Sci. U. S. A., 2017, 114, E1840-E1847.

8.        Jesika Schilder, Wei-Min Liu, Pravin Kumar, Mark Overhand, Martina Huber and Marcellus Ubbink＊ “Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement” Phys. Chem. Chem. Phys., 2016, 18, 5729-5742

9.        Skinner, S. P.; Liu, W. –M.; Hiruma, Y.; Timmer, M.; Blok, A.; Hass, M. A. S.; Ubbink, M.＊ “The delicate conformational balance of the redox enzyme cytochrome P450cam” Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 9022-9027.

10.    Hass, M. A. S.; Liu, W.-M.; Agafonov, R. V.; Otten, R.; Phung, L. A.; Jesika T. Schilder, J. T.; Kern, D.; Ubbink, M.＊ “A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy” J. Biomol. NMR 2015, 61, 123-136.

11.    Camacho-Zarco, Aldo R.; Munari, F.; Wegstroth, M.; Liu, W.-M.; Ubbink M.; Becker, S.; Zweckstetter, M＊ “Multiple Paramagnetic Effects through a Tagged Reporter Protein” Angew. Chem. Int. Ed. 2015, 54, 336-339.

12.    Liu, W. –M.; Overhand, M.; Ubbink, M.＊ “The application of paramagnetic lanthanoid ions in NMR spectroscopy on proteins” Coord. Chem. Rev. 2014, 273, 2-12.

13.    Liu, W. –M.; Skinner, S. P.; Timmer, M.; Blok, A.; Filippov, D.; Overhand, M.; Ubbink, M.＊ “A two-armed lanthanoid-chelating paramagnetic NMR probe linked to proteins via thioether linkages” Chem. Eur. J. 2014, 20, 6256-6258.

14.    Hiruma, Y.; Hass, M. A. S.; Kikui, Y.; Liu, W. –M.; Olmez, B.; Skinner, P. S.; Blok, A.; Kloosterman, A.; Koteishi, H.; Loehr, F.; Schwalbe, H.; N­ojiri, M.; Ubbink, M.＊ “The Structure of the Cytochrome P450cam-Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography” J. Mol. Biol., 2013, 22, 4353-4365.

15.    Guan, J.-Y.; Keizers, P. H. J.; Liu, W. –M.; Loehr, F.; Skinner, S. P.; Heeneman, E. A.; Schwalbe, H.; Ubbink, M.＊ and Siegal, G. D.＊ “Small molecule binding sites on proteins established by paramagnetic NMR spectroscopy” J. Am. Chem. Soc. 2013, 135, 5859-5868.

16.    Liu, W. –M.; Keizers, P. H. J.; Hass, M. A. S.; Blok, A.; Timmer, M.; Sarris, A. J. C.; Overhand, M.; Ubbink, M.＊ “A pH-sensitive, Colorful, Lanthanide-chelating Paramagnetic NMR Probe” J. Am. Chem. Soc. 2012, 134, 17306-17313.

17.    Dasgupta, S.; Hu, X.; Keizers, P. H. J.; Liu, W. –M.; Luchinat, C.; Nagulapalli, M.; Overhand, M.; Parigi, G.; Sgheri, L.; Ubbink, M.＊ “Narrowing the conformational space sampled by two domain proteins with paramagnetic probes in both domains” J. Biomol. NMR 2011, 51, 253-263.

 

Book Chapter:

Ru-Yi Youh, Po-Yen Chen, Yen-Cheng Chao, Di-Hua Luo, Hao-Hsiang Chang, Yu-Ling Chang, Wei-Min Liu*, Dean Chou*; Chapter 9: Biomarkers and Applications in Alzheimer’s Disease “Frontiers in Nanobiotechnology Vol. 1, Advances in Biosensing Technology for Medical Diagnosis” Benthem Book