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±Ð±Â(2021.02~) »²¤¯¤j¾Ç¤Æ¾Ç¨t °Æ±Ð±Â(2015.08~2021.01) »²¤¯¤j¾Ç¤Æ¾Ç¨t §U²z±Ð±Â(2010.02~2015.07) »²¤¯¤j¾Ç¤Æ¾Ç¨t ³Õ¤h«á¬ã¨sû(2010) ¥xÆW¤j¾ÇÃÄ¾Ç©Ò ³Õ¤h«á¬ã¨sû(2009) ¬ü°êNorthwestern University ³Õ¤h«á¬ã¨sû(2008) ¥[®³¤jUniversity of Alberta ¤Æ¾Ç³Õ¤h(2007) °ê¥ß¥xÆW¤j¾Ç ³X°Ý³Õ¤h¥Í(2006) ¼w°êUniversity of Münster DAAD ¬ã¨s§U²z(2002) ¤¤¥¡¬ã¨s°|¥Í¤Æ©Ò §U±Ð(2000) ¥xÆW¤j¾Ç¤Æ¾Ç¨t ¤Æ¾ÇºÓ¤h(1999) °ê¥ß¥xÆW¤j¾Ç ¤Æ¾Ç¾Ç¤h(1997) °ê¥ß¤¤¿³¤j¾Ç |
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¼w°ê¾Ç³N¥æ¬y¸pDAAD»P°ê¬ì·|-¤T©úªvpµe¼ú¾Çª÷ 2005-2006 ¬ì§Þ³¡¯S®íÀu¨q¤H¤~¼úÀy(®Õ¤º)-105¡B106¾Ç¦~«× |
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¥»¹êÅç«Ç¬ã¨s¥DÃD¬O¥H¦³¾÷¦X¦¨ (organic synthesis) ªº¤èªk¡A¨Ó»s³Æ¨ã¦³¥Íª«©Î¬O¨ãÃĪ«¬¡©Êªº¦³¾÷¤À¤l¡C¥]§t¤U±´XÓ¥DÃD: (1)
¤ÑµMª«¥þ¦X¦¨ (natural product synthesis)¡A§Q¥Î·sªº¦X¦¨¤èªk»s³Æ¤ÑµMª«¡A¨Ò¦p¡GSCH 71450 (¤@ºØªvÀø¹L°Êªº°t¤è¥ÎÃÄ); ribulose-5-phosphate»Pxylulose-5-phosphate (¤HÅ饳ÁÞÁC»Ä¥NÁ³~®|ªº«n¤¤¶¡¤Æ¦Xª«)¡C (2) ÃĪ«¦X¦¨ (new synthesis of drugs)¡A§Q¥Î·s¶}µoªº¦X¦¨¤èªk¾Ç¨Ó»s³Æ¤wª¾ÃĪ«¡A©Î¬O¨ã¦³ÃĪ«¬¡©Êªº¦³¾÷¤Æ¦Xª«¡A¨Ò¦p¡G Telbivudine (L-dT¡ASEBIVOTM¡ANovartis¡A³ß¥²ºÖ¡A¿ÕµØ¡A·s¤@¥NªvÀøB«¬¨xª¢ªºÃĪ«); Rolipram
(PDE4 inhibitor¡AÁC»ÄÂùà酶4«¬§í¨î¾¯¡A§Ü¼~Æ{»P§Üªü¯÷®üÀq¯gÀø®Ä); Phenylpiracetam (Phenotropil¡A§Ü¼~Æ{»P¥¢´¼¯gÃĪ«); Phenylpiracetam hydrazide (fonturacetam
hydrazide, §ÜÅöíwÀø®Ä) (3)
¶}µo¦X¦¨¤èªk¾Ç (synthetic methodologies)¡A¨Ò¦p: (2-1) §Q¥Îæó°ò²¾¦ì (carbonyl translocation) ªº¦X¦¨¤èªk¾Ç¡A±N«K©yªºÁÞì®Æ (carbohydrate raw material)¡AÂà´«¬°«n©ù¶Q¥Bµ}¦³ªº¦X¦¨«Øºc²Õ¤¸¡AÁÞÃþ¤À¤l¡A©Î¬O¨ã¥Íª«¬¡©Ê¤À¤l¡A¦p: 2-¥h®ñ-L-®ÖÁÞ (2-deoxy-L-ribose)¡A3-¥h®ñ-L-ªG¿} (3-deoxy-L-fructose)¡A®Öà¬ÁÞ (D-ribulose)¡A¤ìà¬ÁÞ (D-xylulose)¡A2-¥h®ñ-L-®ÖÁÞ®Ö苷 (L-deoxyribonucleoside) (2-2) §Q¥Î¤A²m¦Û¥Ñ°ò
(vinyl radical) ¶i¦æipso¦XÀô¤ÏÀ³ (ipso cyclization) ¨Ó¦X¦¨¤ÑµMª«©Î¬OÃĪ«ªºµ²ºc°©¬[¡A¦p: b-f°ò-g-¤ºñQÓi (b-aryl-g-lactam)¡A¤£¹¡©M-b-f°ò-g-¤ºñQÓi (unsaturated-b-aryl-g-lactam)¡C (4)
±±¨îªº¬¡©Ê¦Û¥Ñ°ò»E¦X¤ÏÀ³ (controlled living radical polymerization)¡A¨Ò¦p: ³]p¦X¦¨ÁÞÃþ»E¦Xª«³æÅé¤W§t¦³»PÀù²ÓMªí±¤W¦³ÃöªºÁÞÃþ¤À¤l (tumor-associated carbohydrate antigens)¡A¨Ã§Q¥Î±±¨îªº¬¡©Ê¦Û¥Ñ°ò»E¦X¡A¨Ó»s³Æ¨ã¦³Àù¯g¬ÛÃö§ÜìÁÞ¤À¤l¡A¦pTnªºÁÞÃþ»E¦Xª«¡A§Æ±æ¯à¼ÒÀÀ¦X¦¨ÁÞÃþ§ÜÀù¬Ì] (anticancer vaccines)¡C (5)
³]p»P¦X¦¨¦³¾÷ÃĪ«¤À¤l (design and synthesis of drug-like
molecules)¡A¨Ò¦p:³]p¦X¦¨§ä¥X¨ã°ª«×¿ï¾Ü©Ê¾~¤ùÃþ¨üÅé (opioid receptor) ªº«ú§Ü¾¯ (antagonists)¡A¥Hµo®i·s«¬ªº¤îµh¾¯ (pain killers)¡C |
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¥NªíµÛ§@ |
¥NªíµÛ§@¡G Independent research (¿W¥ß¬ã¨s¤u§@¡A°ß¤@³q°T§@ªÌ) Pei-Ling
Wang (¤ý¨KÕæ), Yi-Xuan Chan (¸âÖöÞ±), Che-Chien Chang* Tetrahedron 2023,
146, 133648. 20. From a Carbohydrate Raw Material to
an Important Building Block: Cost-efficient Conversion of D-Fructose into
2-Deoxy-L-ribose Ya-Han Hsu (³\¶®²[), Che-Chien Chang* J.
Org. Chem. 2022, 87, 13308-13314. 19 Cascade
Vinyl Radical Ipso-Cyclization Reactions and the Formation of a,b-Unsaturated-b-aryl-g-lactams
from N-Propargyl Benzamides Chih-Hao
Luo (ÀdP»¨), Pei-Ling Wang (¤ý¨KÕæ), Che-Chien Chang* J. Org. Chem. 2021, 86,
15033-15044. 18. Conversion of a Readily
Available Carbohydrate Raw Material into a Rare L-Deoxyhexose Ya-Han
Hsu (³\¶®²[), Che-Chien Chang* Tetrahedron Lett. 2021, 63, 152718. 17. Design and Synthesis of Trivalent Tn Glycoconjugate Polymers by
Nitroxide-Mediated Polymerization Si-Xian Liu(¼B«äùÜ), Yun-Tzu
Tsai (½²ªå·O), Yu-Tung Lin (ªL¬ê§Í), Jia-Yue Li(§õ¨ÎéÄ), and Che-Chien
Chang* Tetrahedron 2019, 75, 130776. 16. Synthesis of L-Deoxyribonucleosides from D-Ribose. Wei-Syun Song (§º³¾±), Si-Xian Liu(¼B«äùÜ), and Che-Chien Chang* J. Org. Chem. 2018, 83, 14923-14932. 15. Chemical
Synthesis of Ketopentose-5-phosphates. Wei-Chih Wei (ÃQÞ³§Ó) and Che-Chien
Chang* Eur. J. Org. Chem. 2017, 3033-3040. Àò¿ï¬°·í´Áªº´Á¥Z«Ê±¬G¨Æ: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201700685/full 14. Synthesis
of 3-Deoxy-L-ketohexoses Through Group Transfer. Tai-Ni Lu (¿c©§©g) and Che-Chien Chang* J. Org. Chem. 2016,
81, 469-475. 13. Radical Cyclization Followed by the
Fragmentation of Carbonyl Compounds: Effect of an
alpha-Benzoyl Group. Li-An Chien(²Ày¦w) and Che-Chien Chang* J. Org. Chem. 2015,
80, 11294-11301. 12.
Chemical synthesis of 1-deoxy-L-fructose and L-sorbose
through carbonyl translocation. Hsin-Pei Wu(§dªY»_), Nai-Yun
Hsu(³\¤D¤ª), Tai-Ni Lu
(¿c©§©g), and Che-Chien Chang* Eur. J. Org. Chem. 2015, 378-382. 11. Synthetic
mimics of carbohydrate-based anticancer vaccines: preparation of carbohydrate
polymers bearing unimolecular trivalent carbohydrate ligands by
controlled living radical polymerization. Teng-Yuan
Kuo(³¢Äˤ¸), Li-An Chien(²Ày¦w), Ya-Chi Chang(±i¨Èºö),
Shuang-Yu Liou(¼B¬Û§±),
and Che-Chien Chang* RSC Adv.,
2014, 4, 47066-47075. 10. The absolute stereochemical assignment of SCH 71450, a selective
dopamine D4 receptor antagonist, through the enantioselective
epimer synthesis. Hsin-Pei
Wu(§dªY»_), Tai-Ni Lu (¿c©§©g), Nai-Yun Hsu(³\¤D¤ª),
and Che-Chien Chang* Eur. J. Org. Chem. 2013, 2898-2905. 9. A unique synthetic method to convert a
D-sugar
into 2-deoxy-L-ribitol through carbonyl translocation. Nai-Yun Hsu(³\¤D¤ª) and
Che-Chien Chang* Eur. J. Org. Chem. 2013,
658-661. Selected Invited Lectures («n·|ijÁܽкtÁ¿) Dec
12, 2019, Session 78-3, The 18th
Asian Chemical Congress (18ACC), Taipei, Taiwan ¡§Formal Total Synthesis of Telbivudine
(L-dT)¡¨ Nov 22, 2018, SIL-12A, The 13th
International Symposium on Organic Reactions (ISOR-13), Hsinchu, Taiwan. ¡§Synthesis of
L-Deoxyribonucleosides from D-Ribose¡¨ Apr
22, 2016, SIL-2B, The 12th
International Symposium on Organic Reactions (ISOR-12), Kyoto, Japan. ¡§Carbonyl
Translocation in the Synthesis of Deoxysugars¡¨ May
01, 2015, ¬ì§Þ³¡¦³¾÷¦X¦¨¤p²Õ¬ã°Q·|, ¤¤¿³¤j¾Ç´f»^ªL³õ ¡§Radicals in
the Synthesis of Deoxysugars and Glycopolymers¡¨ Dec
04, 2010, ¤¤°ê¤Æ¾Ç·|¦~·|, ¥xÆW¤j¾Ç®ú¤j¨¹Á¿°ó ¡§Antagonism
of Dihydropyridines Toward Voltage Dependent Ca2+ Channels, Cav1.3
and Cav1.2¡¨ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Before FJCU Postdoc work (Canada and United States) 8.
Farzad Malihi, Derrick. L. J. Clive,* Che-Chien Chang and
Minaruzzaman, Synthetic studies on
CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by
intramolecular conjugate displacement and [2,3]-Wittig rearrangement, J.
Org. Chem. 2013, 78,
996-1013. (with Clive) 7.
Che-Chien
Chang, Song Cao, Soosung Kang, Li Kai, Xinyong Tian,
Prativa Pandey,
Sara Fernandez Dunne, Chi-Hao Luan, D. James Surmeier*, Richard B.
Silverman*, Antagonism of 4-substituted
1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels
Cav1.3 and Cav1.2, Bioorg.
Med. Chem. 2010, 18, 3147-3158. (with Silverman) PhD work (Taiwan and
Germany) 6. Che-Chien Chang, Yu-Hsien Kuo
and Yeun-Min Tsai*, The synthesis of carbohydrate-derived acylsilanes
and their intramolecular free radical cyclization with the formation of
polyoxygenated cyclopentanes, Tetrahedron
Lett. 2009, 50, 3805-3808. (with Tsai) 5. Che-Chien Chang, Kai O. Siegenthaler and Armido Studer*, A
new sterically highly hindered 7-membered cyclic nitroxide for the controlled
living radical polymerization, Helv. Chim. Acta, 2006, 89,
2200-2210. (with Studer) 4. Che-Chien Chang and Armido Studer*, Acceleration of the styryl-TEMPO mediated controlled
radical styrene-polymerization by addition of an efficient alkoxyamine, Macromolecules, 2006, 39, 4062-4068. (with Studer) Before PhD 3. Wen-Bin Yang, Yu-ing Yang, Yu-Feng Gu, Shwu-Huey Wang, Che-Chien Chang, and Chun-Hung
Lin*, Stereochemistry in the synthesis and reaction of exo-glycals, J. Org. Chem. 2002, 67, 3773-3782. 2. Chuan-Fa Chang, Wen-Bin Yang, Che-Chien
Chang and Chun-Hung Lin*, Inter- and intramolecular alcohol additions
to exo-glycals, Tetrahedron Lett. 2002, 43, 6515-6519. 1. Wen-Bin Yang, Chung-Yi Wu, Che-Chien
Chang, Shwu-Huey Wang, Chin-Fen Teo and Chun-Hung Lin*, Facile
synthesis of conjugated exo-glycals,
Tetrahedron lett. 2001, 42, 6907-6910. |
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