師資介紹
|
|
劉維民 助理教授 |
|
|
通訊處 |
辦公室電話：02-2905-2474 實驗室電話：02-2905-3584 |
|
|
E-mail |
||
|
學歷 |
2001.9~2005.6 學士 國立台灣師範大學化學系 2005.9~2007.7 碩士 國立台灣大學化學所 2009.9~2013.11 博士 荷蘭萊頓大學化學所 |
|
|
經歷 |
2007.8~2008.6實習教師
國立中和高級中學 2008.8~2009.7 助教 國立台灣大學化學所 2014.1~2015.1 博士後研究 英國牛津大學化學所 2015.5~2015.12研究員 祥翊製藥股份有限公司 2016.2~ 助理教授 輔仁大學化學系 |
|
|
獎賞 |
l
2008 48th
National and Private High School Science Fair Excellent Work from
Ministry of Education R. O. C. l
2007 Outstanding Graduate
Research Poster Award from
Department of Chemistry, NTU (awarded to top 20% research excellence) l
2007 Excellent Oral Presentation Award from Department of Chemistry, NTU (awarded for clarity of oral presentation) l
2006 Excellent
Organic Graduate Research Poster Award from Chinese Chemical
Society (awarded to top 15% research posters nationwide) |
|
|
學術專長 |
有機化學合成、生物有機 |
|
|
研究領域 |
本實驗室為生物有機實驗室，利用有機化學合成技術開發新穎的合成方法合成具生物活性的小分子化合物。目前實驗室研究主題主要分為三個部分。 1.
開發新穎合成方法合成醣寡聚物及醣綴合物。 2.
利用有機催化劑(organocatalyst)進行不對稱催化反應，合成重要天然物的前驅物。 3.
開發新型小分子螢光探針，用以檢測類澱粉蛋白疾病(第二型糖尿病)，及調查研究該沉澱蛋白之所以發生沉澱的因素，並設計及合成天然物的延伸物用來調控蛋白沉澱的速度，用以減緩其細胞毒性。 |
|
|
受邀演講 |
l
2014.11 Oral presentation at
National Cheng Kung
University l
2013.09 Oral presentation at
Opening of the Paramagnetic NMR
Facility Leiden l
2012.10 Oral presentation at
2012 Annual Meeting of NWO-Chemical Sciences study group meeting for Organic
Chemistry & Synthesis l
2011.04 Oral presentation at
National Wageningen symposium |
|
|
代表著作 |
1.
Shih-Ting
Ma, Chia-Wei Lee and Wei-Min Liu* “Synthesis of 4-thiol-furanosidic
uronate via hydrothiolation reaction” RSC Adv. 2021, 11,
18409. Kuan-Hsuan Su, Chin-Teng Wu, Shang-Wei Lin, Seiji Mori, Wei-Min
Liu*,
and Hsiao-Ching Yang*
“Calculation of CYP450 protein–ligand binding and dissociation
free energy paths” J. Chem. Phys. 2021, 155, 025101. 3.
* and * “A Fluorogenic Molecule for Probing Islet Amyloid
Using Flavonoid as a Scaffold Design” Biochemistry 2020, 59,
1482-1492. 4.
詹璦綺, 林品菡, 劉維民*, 杜玲嫻* “螢光小分子用於偵測類澱粉蛋白聚集” 化學 2020年，第七十八卷，35-47 頁 6. Y.Y.
Dong; H. Wang; A.C.W. Pike; S.A. Cochrane; S. Hamedzadeh; F.J. Wyszyński;
S.R. Bushell; S.F. Royer; D.A. Widdick; A. Sajid; H.I. Boshoff; Y. Park; R.
Lucas; W-M. Liu; S.S. Lee; T. Machida; S. Mehmood; K. Belaya; W. Liu;
A. Chu; L. Shrestha; S.M. Mukhopadhyay; N. Burgess-Brown; M.J. Bibb; C.E.
Barry; C.V. Robinson; D. Beeson; B.G. Davis＊ and E.P. Carpenter＊ “Structures of DPAGT1 Explain
Glycosylation Disease Mechanisms and Advance TB Antibiotic Design” Cell 2018, 175,
1045-1058. 7. Andralojc,
W.; Hiruma, Y.; Liu, W. –M,; Ravera E.; Nojiri M.; Parigi G.;
Luchinat C. and Ubbink M＊ “Identification
of productive and futile encounters in an electron transfer protein
complex“ Proc. Natl. Acad. Sci. U. S. A., 2017, 114,
E1840-E1847. 8. Jesika
Schilder, Wei-Min Liu, Pravin Kumar, Mark
Overhand, Martina Huber and Marcellus Ubbink＊ “Protein docking using an
ensemble of spin labels optimized by intra-molecular paramagnetic relaxation
enhancement” Phys. Chem. Chem. Phys., 2016, 18,
5729-5742 9. Skinner,
S. P.; Liu, W. –M.; Hiruma, Y.; Timmer, M.; Blok, A.; Hass, M. A.
S.; Ubbink, M.＊ “The
delicate conformational balance of the redox enzyme cytochrome P450cam” Proc.
Natl. Acad. Sci. U. S. A., 2015, 112, 9022-9027. 10. Hass, M. A. S.; Liu, W.-M.;
Agafonov, R. V.; Otten, R.; Phung, L. A.; Jesika T. Schilder, J. T.; Kern,
D.; Ubbink, M.＊ “A
minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic
relaxation dispersion NMR spectroscopy” J. Biomol. NMR 2015, 61,
123-136. 11. Camacho-Zarco, Aldo R.; Munari, F.;
Wegstroth, M.; Liu, W.-M.; Ubbink M.; Becker, S.; Zweckstetter, M＊ “Multiple Paramagnetic Effects
through a Tagged Reporter Protein” Angew. Chem. Int. Ed. 2015, 54,
336-339. 12. Liu, W. –M.;
Overhand, M.; Ubbink, M.＊ “The
application of paramagnetic lanthanoid ions in NMR spectroscopy on
proteins” Coord. Chem. Rev. 2014, 273,
2-12. 13. Liu, W. –M.;
Skinner, S. P.; Timmer, M.; Blok, A.; Filippov, D.; Overhand, M.; Ubbink, M.＊ “A two-armed
lanthanoid-chelating paramagnetic NMR probe linked to proteins via thioether
linkages” Chem. Eur. J. 2014, 20,
6256-6258. 14. Hiruma, Y.; Hass, M. A. S.; Kikui,
Y.; Liu, W. –M.; Olmez, B.; Skinner, P. S.; Blok, A.;
Kloosterman, A.; Koteishi, H.; Loehr, F.; Schwalbe, H.; Nojiri, M.; Ubbink,
M.＊ “The
Structure of the Cytochrome P450cam-Putidaredoxin Complex Determined by
Paramagnetic NMR Spectroscopy and Crystallography” J. Mol. Biol., 2013, 22,
4353-4365. 15. Guan, J.-Y.; Keizers, P. H. J.; Liu,
W. –M.; Loehr, F.; Skinner, S. P.; Heeneman, E. A.; Schwalbe, H.; Ubbink,
M.＊ and
Siegal, G. D.＊ “Small
molecule binding sites on proteins established by paramagnetic NMR
spectroscopy” J. Am. Chem. Soc. 2013, 135,
5859-5868. 16. Liu, W. –M.;
Keizers, P. H. J.; Hass, M. A. S.; Blok, A.; Timmer, M.; Sarris, A. J. C.;
Overhand, M.; Ubbink, M.＊ “A
pH-sensitive, Colorful, Lanthanide-chelating Paramagnetic NMR Probe” J.
Am. Chem. Soc. 2012, 134, 17306-17313. 17. Dasgupta, S.; Hu, X.; Keizers, P. H.
J.; Liu, W. –M.; Luchinat, C.; Nagulapalli, M.; Overhand, M.;
Parigi, G.; Sgheri, L.; Ubbink, M.＊ “Narrowing
the conformational space sampled by two domain proteins with paramagnetic
probes in both domains” J. Biomol. NMR 2011, 51,
253-263. Book
Chapter: Ru-Yi Youh, Po-Yen Chen,
Yen-Cheng Chao, Di-Hua Luo, Hao-Hsiang Chang, Yu-Ling Chang, Wei-Min Liu*,
Dean Chou*; Chapter 9: Biomarkers and Applications in Alzheimer’s Disease “Frontiers in
Nanobiotechnology Vol. 1, Advances in Biosensing Technology for Medical
Diagnosis” Benthem Book |
|
